Tag Archives: immunotherapy

Pure Protein L.L.C. Appoints Dr. Rico Buchli as Chief Scientist

OKLAHOMA CITY, Okla. /ScoopCloud/ -- Pure Protein L.L.C. proudly announces the appointment of Dr. Rico Buchli as Chief Scientist. In his new role, Dr. Buchli will lead scientific initiatives and oversee the expansion of the company's immunological products and services portfolio. This strategic move underscores Pure Protein's commitment to providing innovative, high-quality reagents to the global research and diagnostics community.

Dr. Buchli has a distinguished career spanning over two decades, including 23 years as Pure Protein's Director of Research and 3 years as Vice President of Products and Services. He is renowned for his pioneering work in soluble HLA technology, significantly impacting immunotherapy research, particularly in transplant diagnostics and antigen-targeting platforms. His contributions have advanced research in oncology, infectious diseases, and autoimmune diseases, positioning Pure Protein as a leader in HLA reagents and assay platforms.

As Chief Scientist, Dr. Buchli will focus on expanding and refining Pure Protein's product offerings, with an emphasis on delivering superior HLA solutions for research in immunotherapy, transplant diagnostics, and cancer immunology. This will include the development of recombinant monomers, tetramers, and assay platforms essential for T-cell analysis, vaccine development, and understanding autoimmune disorders. His leadership will drive the company's innovation, ensuring the development of customized solutions for its clients while maintaining the highest standards of scientific rigor.

"We are excited to announce the promotion of Dr. Buchli to Chief Scientist," said Tommy Harlan, CEO. "Under his leadership, Pure Protein is poised to continue its legacy of scientific excellence, advancing immunology, oncology, and personalized medicine while expanding its impact on the global research community."

As VP of Products and Services, Dr. Buchli will spearhead efforts to broaden Pure Protein's global reach by fostering collaborations with leading pharmaceutical companies, research institutions, and clinical laboratories, ensuring the accessibility of Pure Protein's cutting-edge tools for medical research. A key priority will be expanding the company's HLA product portfolio to meet growing demand in therapeutic areas by aligning product development with the needs of researchers and clinicians to provide high-quality tools and reagents that drive groundbreaking discoveries.

About Pure Protein, L.L.C.

Pure Protein is a platform technology company funded and managed by Emergent Technologies Inc. For more information about Pure Protein LLC, please visit: http://www.hlaprotein.com/

About Emergent Technologies, Inc.

Emergent Technologies is an innovation solutions and technology commercialization leader headquartered in Austin, Texas. Visit: http://www.etibio.com/

News from Pure Protein LLC

Pure Protein L.L.C. proudly announces the appointment of Dr. Rico Buchli as Chief Scientist. In his new role, Dr. Buchli will lead scientific initiatives and oversee the expansion of the company's immunological products and services portfolio. This strategic move underscores Pure Protein's commitment to providing innovative, high-quality reagents to the global research and diagnostics community.

Related link: https://www.hlaprotein.com/

This version of news story was published on ScoopCloud™ (ScoopCloud.com) - part of and © the Neotrope® News Network - all rights reserved.

iCell Gene Therapeutics Announces cCAR-T Clinical Publication in the Stem Cell Reviews and Reports Journal

STONY BROOK, N.Y. /ScoopCloud/ -- iCell Gene Therapeutics, a clinical stage biopharmaceutical company focused on immunotherapies for hematologic malignancies, solid tumors, organ rejections and autoimmune disorders, today announced the publication of their clinical study utilizing cCAR T-cell immunotherapy to successfully treat a patient with lupus. Their CAR is directed against CD19 and BCMA surface proteins generating a cCAR with dual expression of CD19 and BCMA CAR molecules. Their cCAR is one of a kind in the family of engineered CAR T-cells researchers are studying.

Their report "Treatment of Systemic Lupus Erythematosus Using BCMA-CD19 Compound CAR" published on August 30, 2021, shows the clinical success of cCAR in treating a patient with Systemic Lupus Erythematosus (SLE).

According to Dr. Yupo Ma, founder of iCell Gene Therapeutics, "After a single infusion of CD19-BCMA cCAR the patient achieved undetectable levels of autoantibodies that mediate SLE, successfully treating the patient's SLE for 2 years without the need for additional medications."

The publication is available online at https://doi.org/10.1007/s12015-021-10251-6.

About SLE

Systemic lupus erythematosus (SLE) is an antibody-mediated autoimmune disease, in which autoantibodies attack its own tissues, resulting in widespread tissue damage in the affected organs including kidneys, lungs, joints, brain and blood vessels. According to the Lupus Foundation of America, it estimates that 1.5 million Americans, and at least five million people worldwide, have a form of lupus.

About CD19-BCMA cCAR Therapy

iCell has developed a novel compound Chimeric Antigen Receptor (cCAR)approach. In this approach, the cCAR T cells express two distinct and fully functional CAR molecules, one that targets the molecule CD19 present on B cells and one that targets BCMA, which is present on plasma cells. In their recently published paper, researchers have shown that this cCAR led to rapid and dramatic decreases in B cell levels and levels of "autoantibodies" (antibodies that attack the body's own cells) in a patient with SLE.

As B cells are part of the normal immune system, it is preferable that the elimination of B cells be temporary. After 9 months of B cell depletion, the patient's B cells returned to normal. Importantly, the levels of autoantibodies remained undetectable. Based on these results, the researchers concluded that cCAR effectively "reset" the antibody-producing populations. In this "reset," the problematic cell populations were removed, leaving behind a fresh, clean slate. From this, new B cells and plasma cells were eventually formed, which did not have the same autoantibody-producing properties. Because of this, the patient has not had further lupus symptoms despite receiving no additional medications for over 2 years.

Given the prevalence of antibody-mediated disorders, this cCAR may prove useful for a variety of different medical conditions.

Sjögren's Syndrome, autoimmune hemolytic anemia, neuromyelitis optica spectrum disorder, celiac disease, type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, psoriasis, and multiple sclerosis all incorporate autoantibody formation in disease pathogenesis. Additionally, organ rejection following transplantation may be mediated by antibodies. By "resetting" the immune system prior to organ transplantation, this antibody-mediated rejection may be avoided. More research is needed on the long-term efficacy and safety of this treatment, but future applications of cCAR has a large window of opportunity.

About iCell Gene Therapeutics

iCell Gene Therapeutics, located in Stony Brook, New York, is a clinical-stage biopharmaceutical company developing first-in-class chimeric antigen receptor engineered cells. Their main focuses are on autoimmune disorders, AML, and T-cell malignancies. Their current clinical trials utilize their CARvac, T-cell targeted CARs, cCARs and non-gene edited universal CARs engineered as treatments for cancer, organ rejections and autoimmune diseases. These studies are ongoing in the US and China for their use.

For more information, please visit http://icellgene.com/

CONTACT:
Media and Investors
Kevin Pinz
Tel: (631) 538-6218
Kevin.pinz@icellgene.com

RELATED LINKS:

https://www.lupus.org/resources/how-many-people-have-lupus-in-the-united-states

https://www.lupus.org/resources/what-is-lupus

News from iCell Gene Therapeutics LLC

iCell Gene Therapeutics, a clinical stage biopharmaceutical company focused on immunotherapies for hematologic malignancies, solid tumors, organ rejections and autoimmune disorders, today announced the publication of their clinical study utilizing cCAR T-cell immunotherapy to successfully treat a patient with lupus.

Related link: http://icellgene.com/

This version of news story was published on ScoopCloud™ (ScoopCloud.com) - part of and © the Neotrope® News Network - all rights reserved.